BME Spring Seminar: Translational Optical Micro Imaging Technologies towards Histological Imaging of Biological Tissues in vivo
April 16 @ 12:00 pm - 1:00 pm
Xingde Li, Ph.D.; Professor of Biomedical Engineering, Johns Hopkins
This presentation will focus on our recent progresses on developing high-resolution biophotonic imaging technologies, particularly second-generation optical coherence tomography (OCT) endoscopy and emerging multiphoton endomicroscopy.
These technologies have shown promising translational potential for direct visualization of tissue microanatomies in vivo, in situ and in real time at a resolution from morphological to cellular and subcellular level, which approaches or at standard histopathology but without the need for tissue removal, staining or processing. The physics principles, engineering challenges and solutions will be briefly discussed, including the development of advanced light sources, MEMS technology, custom optical fiber, and ultracompact, high-performance imaging optics. Representative applications of these optical technologies will be presented, including cancer detection, small airway pathophysiology imaging, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on freely walking animals will also be discussed.