BME Spring Seminar: Engineering Human CNS Morphogenesis In Vitro
April 30 @ 12:00 pm - 1:00 pm
Randolph S. Ashton, Ph.D.; Asst. Professor of Biomedical Engineering, University of Wisconsin-Madison
Human pluripotent stem cells (hPSCs) possess the emergent properties necessary to recapitulate developmental processes ex vivo and give rise to organotypic cultures and tissues. If harnessed, these properties could enable scalable manufacture of brain and spinal cord tissue models that closely mimic human neural anatomy and physiology, thereby permitting novel insights into human neurological disorders and even forming the basis for potential neural tissue transplants.
In this presentation, I will describe my lab’s successes in melding hPSC culture with engineering culture systems to reproducibly instruct the earliest stages of CNS morphogenesis. Applications of this technology to develop regenerative cell therapies high-throughput screening platforms for neurotoxins, and novel neurological disease screening assays will also be discussed.