BME Seminar: Picosecond optical responses of hemes: towards label-free redox contrast of the mitochondrial respiratory chain - College of Engineering - University of Wisconsin-Madison BME Seminar: Picosecond optical responses of hemes: towards label-free redox contrast of the mitochondrial respiratory chain - College of Engineering - University of Wisconsin-Madison

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BME Seminar: Picosecond optical responses of hemes: towards label-free redox contrast of the mitochondrial respiratory chain

November 25 @ 12:00 pm - 1:00 pm

Presented by

Jesse Wilson, PhD; Assistant Professor; Electrical & Computer Engineering; Colorado State University

The mitochondrial respiratory chain mediates the flow of electrons from NADH and FADH­2 to oxygen in order to sustain efficient ATP production. Key electron transport proteins, the cytochromes, have unique optical absorption spectra and picosecond responses to light that report on their redox state. Our goal is to build an optical pump-probe experiment that can measure redox of each of the mitochondrial cytochromes and infer electron flow rates within individual mitochondria in live cells and tissues. Potential applications include characterizing metabolic heterogeneity within the tumor microenvironment and diagnostics for mitochondrial disease.

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Date:

November 25

Time:

12:00 pm - 1:00 pm

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Organizer

Department of Biomedical Engineering
Phone:
608-263-4660
Email:
bmehelp@bme.wisc.edu
Website:
https://www.engr.wisc.edu/department/bme/

Venue

Room 1003 (Tong Auditorium) Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706 United States
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