BME Seminar Series: Technical developments for imaging dissolved phase hyperpolarized 129Xe MRI: applications in pulmonary fibrosis
November 19 @ 12:00 pm - 1:00 pm
Sean Fain, Ph.D.; Professor of Radiology and Medical Physics; University of Wisconsin-Madison
Multi-nuclear MRI using hyperpolarized gas agents adds novel capabilities for imaging lung function. Recent advances have led to improved gas polarization levels, more efficient MRI acquisition, and model-based reconstruction to support MR spectroscopic imaging (MRSI) during a breath-hold after inhalation of hyperpolarized xenon-129. The solubility of xenon gas in combination with the new MRSI methods enables resolution of the exchange of the gas into the tissue-capillary “barrier”, and the red blood cell compartments. This capability has expanded the utility of this technology for developing image-based biomarkers of gas exchange. Our work on this project has improved the technologies and developed new acquisition and reconstruction strategies to quantitative measures of gas exchange and apply them to the study of fibrotic lung disease. Idiopathic pulmonary fibrosis in particular is a difficult to treat restrictive lung disease that leads to rapid loss of lung function with severe outcomes of lung transplant or death with a median survival ranging from 2.5 to 3.5 years. We have been working on an NIH funded 4 year project to develop, test, and apply gas exchange MRSI biomarkers of disease progression, and response to anti-fibrotic therapies and will present the status of this project.