BME Seminar Series: Redox-based synthetic biology–towards electrogenetics - College of Engineering - University of Wisconsin-Madison BME Seminar Series: Redox-based synthetic biology–towards electrogenetics - College of Engineering - University of Wisconsin-Madison

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BME Seminar Series: Redox-based synthetic biology–towards electrogenetics

December 3 @ 12:00 pm - 1:00 pm

William E. Bentley Chair of Engineering, Fischell Department of Bioengineering, University of MarylandPresented by

William E. Bentley, Ph.D.; Robert E. Fischell Distinguished Chair of Engineering, Fischell Department of Bioengineering, University of Maryland


We are developing tools of “electrobiofabrication” that enable facile assembly of biological components within devices, including microelectronic devices, that preserve their native biological function. By recognizing that biological redox active molecules are a biological equivalent of an electron-carrying wire, we have developed biological surrogates for electronic devices, including a biological redox capacitor that enable bi-directional “electron” flow. We have also turned to synthetic biology to provide a means to sample, interpret and report on biological information contained in molecular communications circuitry. Finally, we have developed synthetic genetic circuits that enable electronic actuation of gene expression. That is, using simple reconstructions, one can apply voltage on an electrode and directly actuate genetic responses and associated phenotypes. This presentation will introduce the concepts of molecular communication that are enabled by integrating relatively simple concepts in synthetic biology with biofabrication. Our presentation will show how engineered cells represent a versatile means for mediating the molecular “signatures” commonly found in complex environments, or in other words, they are conveyors of molecular communication.

Date:

December 3

Time:

12:00 pm - 1:00 pm

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More Information

Organizer

Department of Biomedical Engineering
Phone:
608-263-4660
Email:
bmehelp@bme.wisc.edu
Website:
https://www.engr.wisc.edu/department/bme/

Venue

Room 1003 (Tong Auditorium) Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706 United States
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