BME Seminar Series: Manu Platt
November 20 @ 12:00 pm - 1:00 pm
“What’s Eating You?”: Quantifying Proteolytic Activity in Health and Disease to Predict Disease Potential
Speaker: Manu Platt
Associate Professor of Biomedical Engineering at Georgia Tech
Wallace H. Coulter Department of Biomedical Engineering Diversity Director
STC on Emergent Behaviors of Integrated Cellular Systems (EBICS), GRA Distinguished Scholar
Patient-to-patient variability in disease progression continues to complicate clinical decisions in diagnosis and treatment. We focused on individual variability in production of cysteine cathepsins, powerful proteases that are the most potent mammalian collagenases and elastases and are upregulated during tissue-destructive disease progression. We study them in the context of tissue remodeling during cancer progression/metastasis and in arterial remodeling, specifically in the vasculature of children with sickle cell disease that have high risks for strokes early in life.
During this seminar, Dr. Platt will discuss:1) experimental and computational tools he has developed to better quantify and model the proteolytic network’s role in disease progression, 2) fundamental insights and consequences of proteolytic network perturbation on extracellular matrix remodeling, and 3) applications in the for personalized medicine strategies to address patient variability in disease progression, while identifying new targets for pharmacological targeting.