BME Seminar Series: Engineering New Tools to Understand Mucus Function and Dysfunction - College of Engineering - University of Wisconsin-Madison BME Seminar Series: Engineering New Tools to Understand Mucus Function and Dysfunction - College of Engineering - University of Wisconsin-Madison

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BME Seminar Series: Engineering New Tools to Understand Mucus Function and Dysfunction

April 29 @ 12:00 pm - 1:00 pm

photo of Gregg DuncanPresented by

Gregg Duncan, Ph.D.; Assistant Professor, Fischell Department of Bioengineering, University of Maryland


Mucus is a biological gel that coats and protects epithelial surfaces in tissues throughout the body. Alterations in the viscoelastic properties of the mucus gel is a hallmark of many diseases, particularly of the lung such as asthma, cystic fibrosis, and chronic bronchitis. However, reliable mucus biomarkers to track changes in these properties as a function of disease have yet to be established. In addition, the process by which mucins create this structure and how it may be altered in the context of disease is poorly understood due to the lack of suitable model systems. Towards this end, I will describe in this talk the development of (i) a nanoparticle-based detection scheme to assess disease-associated mucus defects and (ii) a physiologically relevant mucin-based hydrogel platform. Together, these tools may provide the means to fundamentally understand the role of mucus in the progression of diseases and more effectively diagnose patients.

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Date:

April 29

Time:

12:00 pm - 1:00 pm

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Organizer

Department of Biomedical Engineering
Phone:
608-263-4660
Email:
bmehelp@bme.wisc.edu
Website:
https://www.engr.wisc.edu/department/bme/

Venue

Room 1003 (Tong Auditorium) Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706 United States
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