BME Seminar Series: Unraveling the function of the non-coding genome in human disease - College of Engineering - University of Wisconsin-Madison BME Seminar Series: Unraveling the function of the non-coding genome in human disease - College of Engineering - University of Wisconsin-Madison

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BME Seminar Series: Unraveling the function of the non-coding genome in human disease

October 25 @ 12:00 pm - 1:00 pm

profile photo of Valentina Lo SardoPresented By

Valentina Lo Sardo, PhD; Assistant Professor, Department of Cell and Regenerative Biology; University of Wisconsin–Madison

Dr. Lo Sardo’s research interest is directed at understanding genetic variations linked to cardiovascular disease susceptibility and identifying their functional consequences at the cellular level. Genome-wide association studies provide increasing evidence of linkage between common genetic variants and complex disease susceptibility. One of the most challenging problems in studying human disease biology is the influence of mutations in non-coding regions. Yet, these are the most common regions identified with genome association studies. Although the number of genetic variants linked to cardiovascular disease continues to grow, their functional impact on human physiology remains largely obscure. Research in the Lo Sardo lab combines pluripotent stem cell potential and functional genomics to understand how common genetic variants among individuals, including those in non-coding portions of the genome, contribute to altering cell physiology, cell state, and fate commitment. Emphasis is posed on understanding non-coding risk factors, cell-type vulnerability, as well as ethnicity-based vulnerability to cardiovascular disease.

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Date:

October 25

Time:

12:00 pm - 1:00 pm

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More Information

Organizer

Department of Biomedical Engineering
Phone:
608-263-4660
Email:
bmehelp@bme.wisc.edu
Website:
https://www.engr.wisc.edu/department/bme/

Venue

Room 1003 (Tong Auditorium) Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706 United States
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