Research Associate
Edward J. Sambriski
- University of Wisconsin-Madison Genomic Sciences Training Program Postdoctoral Fellow (2007-present)
Education
- B.S., Chemistry, San José State University, 2001
- M.S., Chemistry, University of Oregon, 2002
- Ph.D., Chemistry, University of Oregon, 2006
Research Interests
Hailed by many as the molecule of life, DNA is indeed central to the development and function of all living organisms and certain viruses. Treating the rich gamut of physics of DNA in the realm of science and engineering remains a challenge for atomistic representations in conventional computer simulation methods. Armed with the tools of statistical mechanics and novel simulation techniques, my research is aimed at the construction of a mesoscopic representation of DNA, with nanoscale resolution, to facilitate the acquisition of length and timescales beyond the nanoscale. Goals are geared toward the elucidation of fundamental events and processes related to DNA confinement, compaction, and self-assembly of nucleic acids. Direct applications include viral encapsidation, nucleosome packing, and the fabrication of patterned nanostructures. By ushering a set of computational tools that curb the expensive resources that conventional simulation methods entail, we can provide an alternative edge to understanding problems of physical and biological relevance while narrowing the knowledge gap that presently exists between experimental and computational studies.
Contact
Dr. Edward J. Sambriski
Department of Chemical and Biological Engineering
University of Wisconsin-Madison
1037 Engineering Hall
1415 Engineering Drive
Madison, WI 53706-1691
U.S.A.
tel: +1 608 262-2448
fax: +1 608 262-5434
email: sambriski@wisc.edu
