Contact Information

Room 101 1410 Engineering Drive Madison, WI 53706

Tel: 608/265-2944 Fax: 608/262-3632 E-mail: manolach@engr.wisc.edu

Program Affiliations

• Engineering Physics

Duties and Responsibilities

• Research Interest
• Plasma chemistry and plasma polymerization, including synthesis of nanoparticles
• Plasma-induced functionalization of organic and inorganic substrates, including biotech applications
• Chromatography, mass spectrometry and hyphenated techniques for diagnostic of complex systems
• Chemical Evolution and complex plasma systems
• Computational chemistry, modeling and simulation, information on chemical systems
• Development of novel low- and atmospheric-pressure, plasma-enhanced reaction mechanisms and related technologies for surface functionalization of natural and synthetic polymeric substrates
• Design and development of original plasma-chemistry tools

Selected Awards, Honors and Societies

• Photopolymer Science and Technology Award - Japan, Chiba - 2000.
• 2002-Present American Chemical Society, Full Member (Polymer Division)
• 2000-2002 American Chemical Society, Affiliate Member (Polymer Division)

Selected Publications

• S. Manolache, C-tin Romanescu, Ghe. Cobileac and C. I. Simionescu, Some Terpenes and Related Derivatives Synthesized in Cold Plasma Systems, Molecules 2(11), 158-164 (1997).
• F. Denes, S. Manolache and R. A. Young, Synthesis and Surface Functionalization under Cold-Plasma Conditions, J. Photopolymer Science and Technology 12 (1), 27-38 (1999).
• S. Manolache, M. Sarfaty and F. Denes, RF-Frequency Effects on Molecular Fragmentation, Plasma Sources Science and Technology 9, 37-44 (2000).
• C. Naum, S. Manolache and F. Denes, Synthesis of Teflon-like Thin Layers under Perfluoro-1-butanesulfonyl Fluoride / Methane RF-Plasma Environments, Langmuir 16(2), 749-753 (2000).
• A. J. Martínez, S. Manolache, V. González, R. A. Young and F. Denes, Immobilized Biomolecules on Plasma Functionalized Cellophane. I. Covalently Attached -Chymotrypsin, J. Biomaterials Science. Polymer Edition 11(4), 415-438 (2000).
• S. Manolache and F. Denes, Synthesis of Nanoparticles under Cold-Plasma Conditions, J. Photopolymer Sci. Technol. 13(1), 51-62 (2000).
• R. Ganapathy, S. Manolache, M. Sarmadi, W. J. Simonsick Jr. and F. Denes, Immobilization of Active -Chymotrypsin on RF-Plasma-Functionalized Polymer Surfaces, J. of Applied Polymer Science 78(10), 1783-1796 (2000).
• Y. C. Ma, S. Manolache, M. Sarmadi, and F. Denes, Plasma-Enhanced Synthesis of Maltodextrin-Polydimethylsiloxane Graft-Copolymers, J. Appl. Polymer Sci. 80(8), 1120-1129 (2001).
• V. A. Shamamian, D. D. Hinshelwood, D. C. Guerin, F. S. Denes, and S. Manolache, Mass Spectrometric Characterization of Pulsed Inductively Coupled Plasmas for Deposition of Thin Polyethylene Glycol-like Polymer Films, J. Photopolymer Sci. Technol. 14 (2001).
• S. Manolache, E. B. Somers, A. C. L. Wong, V. Shamamian and F. Denes, Dense Medium Plasma Environments: A New Approach for the Disinfection of Water, Environmental Science and Technology 18, 3780-3785 (2001).
• R. Ganapathy, S. Manolache, M. Sarmadi, and F. Denes, Immobilization of Papain on Cold-Plasma-Functionalized Polyethylene and Glass Surfaces, J. Biomater. Sci. Polymer Edn 12(9), 1027-1049 (2001).
• S. Alvarez-Blanco, S. Manolache, and F. Denes, A Novel Plasma-enhanced Way for Surface-Functionalization of Polymeric Substrates, Polymer Bulletin 47, 329-336 (2001).
• Y. J. Wu, A. J. Griggs, J. Jen, S. Manolache, F. Denes and R. B. Timmons, Pulsed Plasma Polymerization of Cyclic Ethers: Production of Biologically Non-Fouling Surfaces, Plasmas and Polymers 6(3), 123-144 (2001).
• H. T. Sahin, S. Manolache, R. A. Young and F. Denes, Surface Fluorination of Paper under CF4 – RF Plasma Environments, Cellulose 9(2), 171-181 (2002).
• L. G. Paterno, S. Manolache, and F. Denes, Synthesis of Polyaniline-type Thin Layer Structures Under Low-Pressure RF-Plasma Conditions, Synthetic Metals 130(1), 85-97 (2002).
• A. R. Martin, S. Manolache, F. S. Denes, L. H. C. Mattoso, Functionalization of sisal fibers and high-density polyethylene by cold plasma treatment, Journal of Applied Polymer Science 85(10), 2145-2154 (2002).
• L. E. Cruz-Barba, S. Manolache, and F. Denes, Novel Plasma Approach for the Synthesis of Highly Fluorinated Thin Surface Layers, Langmuir 18, 9393-9400 (2002).
• S. Alvarez-Blanco, S. Manolache, and F. Denes, Synthesis of Polyaniline Using Horseradish Peroxidase Immobilized on Plasma-Functionalized Polyethylene Surfaces as Initiator, Journal of Applied Polymer Science 88(2), 369-379 (2003).
• F. S. Denes, S. Manolache, Y. Ma, V. Shamamian, B. Ravel, and S. Prokes, Dense Medium Plasma Synthesis of Carbon/Iron-based Magnetic Nanoparticle Systems, J. Appl. Phys. 94(5), 3498-3508 (2003).
• L. E. Cruz-Barba, S. Manolache and F. Denes, Generation of Teflon-like layers on cellophane surfaces under atmospheric pressure non-equilibrium SF6-plasma environments, Polymer Bulletin 50(5-6), 381-387 (2003).
• Y. Wang, S. Manolache, A. C. L. Wong, and F. S. Denes, Cold Plasma Synthesis of Poly(ethylene glycol)-like Layers on Stainless Steel Surfaces to Reduce Attachment and Biofilm Formation by Listeria Monocytogenes, Journal of Food Science 68(9), 2772-2779 (2003).
• D. C. Johnson, V. A. Shamamian, J. H. Callahan, F. S. Denes, S. O. Manolache and D. S. Dandy, Treatment of methyl tert-butyl ether contaminated water using a Dense Medium Plasma Reactor: A Mechanistic and kinetic investigation, Environmental Science and Technology 37, 4804-4810 (2003).
• Y. Ma, S. Manolache, M. Sarmadi and F. S. Denes, Synthesis of starch copolymers by silicon tetrachloride plasma-induced graft polymerization, Starch / Staerke 56(2), 47-57 (2004).
• S. Manolache, V. Shamamian and F. Denes, DMP Plasma-Enhanced Decontamination of Water of Aromatic Compounds, Journal of Environmental Engineering 130(1), 17-25 (2004).
• F. Denes and S. Manolache, Macromolecular Plasma-Chemistry: an Emerging Field of Polymer Science, Progress in Polymer Science 29(8), 815-885 (2004).
• H. Jiang, S. Manolache, A.C.L. Wong and F. Denes, Plasma-enhanced Deposition of Silver Nanoparticles onto Polymer and Metal Surfaces for the Generation of Antimicrobial Characteristics, Journal of Applied Polymer Science 93(3), 1411-1422 (2004).
• Y. Ma, S. Manolache, F. S. Denes, D. Vail, D. Thamm, and I. Kurzman, Immobilization of Doxorubicin on Surfaces of Plasma Synthesized C/Fe and C/Fe/N Magnetic Nanoparticles for Targeted Drug Delivery, Journal of Biomaterial Science Polymer Edition 15(8), 1033-1049 (2004).
• S. N. Jampala, S. Manolache, S. Gunasekaran and F. S. Denes, Plasma-enhanced Modification of Xanthan Gum and its Effect on Rheological Properties, Journal of Agricultural and Food Chemistry 53(9), 3618-3625 (2005).
• B. Dong, S. Manolache, E. B. Somers, A. C. L. Wong and F. S. Denes, Generation of Antifouling Layers on Stainless Steel Surfaces by Plasma-Enhanced Crosslinking of Polyethylene Glycol, Journal of Applied Polymer Science 97(2), 485-497 (2005).
• B. J. Larson, J. M. Helgren, S. O. Manolache, A. Y. Lau, M. G. Lagally and F. S. Denes, Cold-plasma modification of oxide surfaces for covalent biomolecule attachment, Biosensors and Bioelectronics 21, 796-801 (2005).
• S. Alvarez, A. Garcia, S. Manolache, F. Denes, F. A. Riera, R. Alvarez, Plasma-enhanced modification of the pore size of ceramic membranes. Desalination 184(1-3), 99-104 (2005).
• Y. Ma, S. Manolache, F. Denes, J. Cho, and R. Timmons, Surface modification of rutile TiO2 by submerged arc for improved photoreactivity, Journal of Materials Engineering and Performance 15, 370-375 (2006).
• Y. Ma, S. Manolache, F. Denes, D. Vail, D. Thamm, and I. Kurzman, Plasma synthesis of carbon-iron magnetic nanoparticles and immobilization of doxorubicin for targeted drug delivery, Journal of Materials Engineering and Performance 15, 376-382 (2006).
• H. Jiang, S. Manolache, E. B. Somers, A.C. Wong and F.S. Denes, Synthesis of Dendrimer-type Poly (ethylene glycol) Structures from Plasma-functionalized Silicone Rubber Surfaces, Journal of Applied Polymer Science 102(3), 2324-2337 (2006).
• F. Denes and S. Manolache, Immobilization of Active Biopolymers from Cold-Plasma-Functionalized Surfaces for the Creation of Molecular-Recognition and Molecular Manufacturing Systems (Chapter 12), in: S. Dumitriu (Ed), Polymeric Biomaterials: Second Edition, Revised and Expanded, Marcel Dekker Inc., New York, p. 239-290 (2002).
• F. Denes, S. Manolache, and L. E. Cruz-Barba, Low-pressure Versus Atmospheric-pressure Non-equilibrium Plasma-enhanced Surface Modification of Cellulosic Substrates, 6th Pacific Rim Bio-based Composites Symposium, November 10-13, p. 517-527, Portland OR (2002).
• F. S. Denes, L. E. Cruz-Barba and S. Manolache, Plasma Treatment of Wood, (Chapter 16), in: R. M. Rowell (Ed), Handbook of Wood Chemistry and Wood Composites, CRC Press, p. 447-473 (2005).
• Patents
• Method and Device for Micromeasurement - Microencapsulation of Biologic Active Compounds, C. I. Simionescu, S. Manolache, M. Popa, S. Dumitriu and D. Marin, 03.30.1987, RSR 92373.
• Device for Micromeasurement - Microencapsulation, C. I. Simionescu, S. Manolache, M. Popa, S. Dumitriu and D. Marin, 07.08.1988, RSR 96553.
• Device for Chemical Synthesis in Dense Medium Plasma Conditions, C. I. Simionescu, F. Denes and S. Manolache, 12.15.1993, RO 103645 (C08F2/58).
• Device for Thin Film Deposition in High Frequency Plasma, C. I. Simionescu, F. Denes, S. Manolache, C. Badea and T. Besliu, 11.10.1994, RO 109223.
• Method for DLC Film Deposition in High Frequency Plasma, C. I. Simionescu, F. Denes, S. Manolache, C. Badea and T. Besliu, 1997, RO 111947 B1.
• Method for Film Deposition of Polycrystaline Silicium Carbide in High Frequency Plasma, C. I. Simionescu, F. Denes, S. Manolache, C. Badea and T. Besliu, 1997, RO 111948 B1.
• Process for the Intercalation of Spacer Molecules between Substrates and Active Biomolecules, F. Denes, S. Manolache, M. Sarmadi, R. A. Young, R. Ganapathy and A. J. Martinez-Gomez, 06/11/2002, US 6402899.
• Cold Plasma Treatment of Seeds to Remove Surface Materials, F. Denes, S. Manolache, R. A. Young and J. Volin, 04/08/2003, US 6543460 B1.
• Method for Disinfecting a Dense Fluid Medium in a Dense Medium Plasma Reactor, F.S. Denes, S.O. Manolache, A.C.L. Wong, and E.B. Somers, 06/15/2004, US 6749759 B2.
• Plasma Generator, F. S. Denes, S. O. Manolache and N. Hershkowitz, 7/20/2004, US 6764658 B2.
• Method and Apparatus for Producing Colloidal Nanoparticles in a Dense-Medium-Plasma, F. Denes, S. Manolache, and N. Hershkowitz, 10/31/2006, US 7128816 B2.
• Hard-Carbon Films Formed from Plasma Treated Polymer Surfaces, F. Denes, S. Manolache and L. E. Cruz-Barba (11/21/2006) US 7138180.

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