Ogle, Brenda M.

Ogle BM, Gairola P and Mooradian DL. Tissue Engineering: An emerging field at the interface between engineering, biology, and medicine. Minnesota Academy of Science 62(2):47-57. 1998.

Ogle BM and Mooradian, DL. The role of vascular smooth muscle cell integrins in the compaction and mechanical strengthening of a tissue engineered blood vessel. Tissue Engineering 5(4):387-402. 1999.

Ogle BM and Mooradian, DL. Manipulation of remodeling pathways to enhance the mechanical properties of a Tissue Engineered Blood Vessel. Journal of Biomechanical Engineering 124:724-733. 2002.

Maio RMFM, Ogle BM, Platt JL. Ways to replace the function of failing organs. Organs and Tissues 5:11-15. 2002.

Ogle BM and Platt JL. Genetic therapies in xenotransplantation. Expert Opinion on Biological Therapy 2(3):299-310. 2002.

Ogle BM and Platt JL. Approaches to the replacement of the function of failing organs. Current Opinion in Organ Transplantation 7(1):28-34. 2002.

Ogle BM, Cascalho M, Joao CM, Taylor W, West LJ, Platt JL. Direct measurement of lymphocyte receptor diversity. Nucleic Acids Research 31(22):e139. 2003.

Ogle BM, Butters KB, Plummer TB, Ring KR, Knudsen B, Litzow MR, Cascalho M, Platt JL. Spontaneous fusion of cells between species yields transdifferentiation and retroviral transfer in vivo. FASEB Journal 18:548-550. 2004.

Ogle BM, Cascalho M, Platt JL. Fusion of approaches to the treatment of organ failure. American Journal of Transplantation 4(6):74-77. 2004.

Jo�o CM, Ogle BM, Gay-Rubenstein C, Platt JL, Cascalho M. B cell-dependent TCR diversification. Journal of Immunology 172(8):4709-4716. 2004.

Cascalho M, Ogle BM, Platt JL. Xenotransplantation and the future of renal replacement. Journal of the American Society of Nephrology 15:1106-1112. 2004.

Ogle BM and Platt JL. The biology of cell fusion. American Scientist 92(5):420-427. 2004.

Cascalho M, Ogle BM, Platt JL. New approaches to replacing failing organs. Transplant Proceedings 36:1629. 2004.

Ogle BM and Platt JL. “Xenografts” in Encyclopedia of Biomaterials and Biomedical Engineering. eds, Wnek G and Bowlin G. Marcel Dekker, Inc. NY. pp. 1780-1789. 2004.

Ogle BM, Cascalho M, Platt JL. Biologic implications of cell fusion. Nature Reviews Molecular Cell Biology 6(7):567-575. 2005.

Cascalho M, Ogle BM and Platt JL. “Emerging Strategies in Kidney Transplantation” in Chronic Kidney Disease, Dialysis & Transplantation. eds, Pereira BJG, Sayegh MH, Blake PG. Elsevier Saunders, Philadelphia, PA. pp. 750-758. 2005.

Ogle BM, Platt JL. “Genetic engineering of organs” in Encyclopedia of Biomaterials and Biomedical Engineering. eds, Wnek G and Bowlin G. Marcel Dekker, Inc. NY. In Press.

Ogle BM, West LJ, Driscoll DJ, Strome SE, Razonable RR, Paya CV, Cascalho M, Platt JL. Effacing of the T cell compartment by cardiac transplantation in infancy. Journal of Immunology 176:1962-1967. 2006.

Ogle BM and Platt JL. “Xenotransplantation” in Encyclopedia of Biomedical Engineering. eds, Akay, M. John Wiley & Sons, Inc. NJ. In Press.

Ogle BM, Knudsen BE, Nishitai R, Ogata K and Platt JL. Toward development of T cells in swine. Submitted 2006.

Selected Awards, Honors and Societies

CURRENT AWARDS

2004 NIH Quantitative Research Career Development Grant.

PROFESSIONAL SOCIETIES

Biomedical Engineering Society 1996 to present

Society for Biomaterials 1997 to present

Phi Kappa Phi, Engineering Honor Society 1997 to present

Summary

The overall goal of this laboratory is to transform the theories of regenerative medicine into clinical practice. This popular new field has been slow to progress not for lack of novel concepts but for lack of testable solutions. The solutions we envision stem in part from an in vivo model system we have developed wherein human stem cells undergo fusion (in some cases), differentiation and expansion in animals. We are currently using this system to develop a tissue engineered thymus that would serve to reconstitute immunity in patients who suffer immunodeficiency as a result of cardiac transplantation. We plan to apply the insights gained from this work to other organ systems, especially but not limited to the cardiovascular system.

Files and Links of Interest

System Regeneration Laboratory

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Date last modified: 08-Oct-2007
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