Ogle, Brenda M.

1. Ogle BM and Mooradian, DL. The role of vascular smooth muscle cell integrins in the compaction and mechanical strengthening of a tissue engineered blood vessel. Tissue Engineering 5(4):387-402. 1999.

2. Ogle BM and Mooradian, DL. Manipulation of remodeling pathways to enhance the mechanical properties of a Tissue Engineered Blood Vessel. Journal of Biomechanical Engineering 124:724-733. 2002.

3. Maio RMFM, Ogle BM, Platt JL. Ways to replace the function of failing organs. Organs and Tissues 5:11-15. 2002.

4. Ogle BM and Platt JL. Genetic therapies in xenotransplantation. Expert Opinion on Biological Therapy 2(3):299-310. 2002.

5. Ogle BM and Platt JL. Approaches to the replacement of the function of failing organs. Current Opinion in Organ Transplantation 7(1):28-34. 2002.

6. Ogle BM, Cascalho M, Joao CM, Taylor W, West LJ, Platt JL. Direct measurement of lymphocyte receptor diversity. Nucleic Acids Research 31(22):e139. 2003.

7. Ogle BM, Butters KB, Plummer TB, Ring KR, Knudsen B, Litzow MR, Cascalho M, Platt JL. Spontaneous fusion of cells between species yields transdifferentiation and retroviral transfer in vivo. FASEB Journal 18:548-550. 2004.

8. Ogle BM, Cascalho M, Platt JL. Fusion of approaches to the treatment of organ failure. American Journal of Transplantation 4(6):74-77. 2004.

9. Joao CM, Ogle BM, Gay-Rubenstein C, Platt JL, Cascalho M. B cell-dependent TCR diversification. Journal of Immunology 172(8):4709-4716. 2004.

10. Cascalho M, Ogle BM, Platt JL. Xenotransplantation and the future of renal replacement. Journal of the American Society of Nephrology 15:1106-1112. 2004.

11. Ogle BM and Platt JL. The biology of cell fusion. American Scientist 92(5):420-427. 2004.

12. Cascalho M, Ogle BM, Platt JL. New approaches to replacing failing organs. Transplant Proceedings 36:1629. 2004.

13. Ogle BM and Platt JL. Xenografts in Encyclopedia of Biomaterials and Biomedical Engineering. eds, Wnek G and Bowlin G. Marcel Dekker, Inc. NY. pp. 1780-1789. 2004.

14. Ogle BM, Cascalho M, Platt JL. Biologic implications of cell fusion. Nature Reviews Molecular Cell Biology 6(7):567-575. 2005.

15. Cascalho M, Ogle BM and Platt JL. Emerging Strategies in Kidney Transplantation in Chronic Kidney Disease, Dialysis & Transplantation. eds, Pereira BJG, Sayegh MH, Blake PG. Elsevier Saunders, Philadelphia, PA. pp. 750-758. 2005.

16. Ogle BM and Platt JL. Xenotransplantation in Encyclopedia of Biomedical Engineering. eds, Akay, M. John Wiley & Sons, Inc. NJ. 2006.

17. Ogle BM, West LJ, Driscoll DJ, Strome SE, Razonable RR, Paya CV, Cascalho M, Platt JL. Effacing of the T cell compartment by cardiac transplantation in infancy. Journal of Immunology 176:1962-1967. 2006.

18. Ogle BM, Platt JL. Genetic engineering of organs in Encyclopedia of Biomaterials and Biomedical Engineering. eds, Wnek G and Bowlin G. Marcel Dekker, Inc. NY. 2007.

19. Cascalho M., Ogle BM and Platt JL. New approaches to organ transplantation in Living Donor Organ Transplantation. ed, Gruessner R. McGraw-Hill Professional, NY. pp. 692-704. 2007.

20. Ogle BM, Knudsen BE, Nishitai R, Ogata K and Platt JL. Toward development and production of human T cells in swine for potential use in adoptive T cell immunotherapy. Tissue Engineering Sept 30 2008 [epub ahead of print].

21. Lin H and Ogle BM, Nuclear reprogramming in Encyclopedia for Stem Cell Research. Sage Publications, CA. pp. 369-399. 2008.

22. McNeill EM and Ogle BM. Active learning through teaching in an extracellular matrix engineering course for biomedical engineering graduate students. Proceedings of the 2008 ASEE North Midwest Sectional Conference 2008.

23. Santiago J, Pogemiller R, Ogle BM. Heterogeneous differentiation of human mesenchymal stem cells in response to extended culture in extracellular matrices. Tissue Engineering. 2009. 15(12):3911-3922.

24. Buschke DG, Squirrell JM, Ansari H, Smith M, Rueden CT, Williams JC, Lyons, G, Kamp TJ, Eliceiri KW, Ogle BM. Multiphoton flow cytometry to assess intrinsic and extrinsic fluorescence in cellular aggregates: applications to stem cells. Microscopy and Microanalysis. 2010. 15:238-255.

25. Lin HP, Vincenz C, Eliceiri KW, Kerppola T, Ogle BM. Biomolecular fluorescence complementation analysis of eukaryotic fusion products. Biology of the Cell 2010. 102:525-537

26. Buschke DG, Eliceiri K, Ogle BM. Screening Approaches for Stem Cells in Stem Cell and Tissue Repair, Royal Society of Chemistry. 2010.

27. McConnico A, Butters K, Knudsen BE, Platt, JL, Ogle BM. In utero transfer of cells between porcine littermates. Reproduction, Fertility and Development. 2010.

Selected Awards, Honors and Societies

CURRENT AWARDS

NIH Training Fellowship, Mayo Clinic Digestive Disease 2001, 2002

NIH Training Fellowship, Mayo Clinic Nephrology 2003, 2004

NIH Mentored Career Award 2004

Polygon Outstanding Professor Award, UW College of Engineering 2007

Edward P. Mikol Best Paper Award, ASEE 2008

NSF CAREER Award 2009

PROFESSIONAL SOCIETIES

Biomedical Engineering Society 1996 to present

Society for Biomaterials 1997 to present

Phi Kappa Phi, Engineering Honor Society 1997 to present

American Society of Mechanical Engineers 1999 to present

Tissue Engineering and Regenerative Medicine International Society 2005 to present

American Society of Engineering Education 2006 to present

International Society for Stem Cell Research 2008 to present

Summary

The overall goal of this laboratory is to transform the theories of regenerative medicine into clinical practice. This popular new field has been slow to progress not for lack of novel concepts but for lack of testable solutions. The solutions we envision stem in part from an in vivo model system we have developed wherein human stem cells undergo fusion (in some cases), differentiation and expansion in animals. We are currently delving more deeply into the mechanisms that govern stem cell fusion. We plan to apply the insights gained from this work to enhance efforts to regenerate heart tissue. In addition, we plan to build new technologies to enable advanced analysis of stem cells including, multiphoton flow cytometry.

Date last modified: 19-Aug-2011
Content by: ogle@wisc.edu
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