William L. Murphy Associate Professor Address/E-mail Program Affiliations Courses Education Fields of Interest Publications Awards & Honors Files and Links >>> Extended Homepage <<<

Contact Information

Primary Address: 3152 Engineering Centers Building 1550 Engineering Drive Madison, WI 53706 Tel: 608/262-2224 Fax: 608/265-9239 E-mail: wlmurphy@wisc.edu

Secondary Address: 5009 Wisconsin Institute for Medical Research 1111 Highland Drive Madison, WI 53705 Tel: 608/265-9978

Program Affiliations

• Biomedical Engineering
• Materials Science and Engineering
• Pharmacology

• Biomedical Engineering Center for Translational Research
• Materials Science Program
• Orthopedics and Rehabilitation
• Smart, Bioinspired Materials Laboratory

Courses

• BME 301: Biomedical Engineering Design
• BME 520: Stem Cell Bioengineering

Education

• Postdoctoral Fellow 2002-2004, University of Chicago
• PhD 2002, University of Michigan-Ann Arbor
• MS 2000, University of Michigan-Ann Arbor
• BS 1998, Illinois Wesleyan University

Fields of Interest

• Creation of new biomaterials using bioinspired approaches
• Using biomaterials to define the stem cell microenvironment
• Development of biomaterials for tissue regeneration (tissue engineering)
• New approaches for drug delivery and gene therapy

Publications

• Z. Sui, W.J. King, W.L. Murphy. Dynamic materials based on a protein conformational change. Advanced Materials, 2007;19:3377-3380.
• G. Hudalla, T.S. Eng, W.L. Murphy. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks, Biomacromolecules, 2008; 9:842-849.
• L. Jongpaiboonkit, W.J. King, G.E. Lyons, A. Paguirigan, J. Warrick, D.J. Beebe, W.L. Murphy, Adaptable hydrogel array format for 3-dimensional cell culture, Biomaterials, 2008;29:3346-3356.
• Z. Sui, W.J. King, W.L. Murphy. Protein-based hydrogels with tunable dynamic responses, Advanced Functional Materials, 2008;18:1824-1831.
• S. Choi, W.L. Murphy. Multifunctional mixed SAMs that promote both cell adhesion and non-covalent DNA immobilization, Langmuir, 2008; 24:6873-6880.
• B.J. Peret, W.L. Murphy. Controllable soluble protein concentration gradients in hydrogel networks, Advanced Functional Materials, 2008; 18: 3410-3417.
• J.W. Warrick, W.L. Murphy, D.J. Beebe. Screening the cellular microenvironment: A role for micro-scale culture. IEEE Review of Biomedical Engineering, 2008; 1: 75-94.
• L. Jongpaiboonkit, W.J. King, W.L. Murphy. Screening for 3-D environments that support human mesenchymal stem cell viability using hydrogel arrays, Tissue Engineering A, 2009;15:343-353.
• L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Mineral-coated, biodegradable microspheres for controlled protein binding and release, Advanced Materials, 2009;21:1960-1963.
• W.L. Murphy, J.H. Collier. Self-assembling biomaterials, Acta Biomaterialia, 2009;5:803-804.
• G.A. Hudalla, W.L. Murphy. Using �click� chemistry to prepare substrates to study stem cell adhesion, Langmuir, 2009;25:5737-5746.
• J. Shaikh Mohammed, W.L. Murphy. Bioinspired design of dynamic materials. Advanced Materials, 2009;21:2361-2374.
• W.J. King, J.Shaikh Mohammed, W.L. Murphy. Modulating growth factor release from hydrogels via a protein conformational change. Soft Matter, 2009; 5: 2399-2406.
• K.J. Regehr, M. Domenech, J.T. Koepsel, K.C. Carver, S.J. Ellison-Zelski, W.L. Murphy, L.A. Schuler, E.T. Alarid, D.J. Beebe. Biological implications of polydimethylsiloxane-based microfluidic cell culture, Lab on a Chip, 2009; 9: 2132-2139.
• J.S. Lee, J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation, Angewandte Chemie Int. Ed., 2009; 48: 6266-6270.
• L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Fabrication and characterization of mineral-coated poly(lactide-co-glycolide) microspheres, ACS Applied Materials and Interfaces, 2009; 1: 1504-1511.
• J.T. Koepsel, W.L. Murphy. Patterning discrete stem cell culture environments via localized SAM replacement, Langmuir, 2009; 25: 12825-34.
• Y. Lu, M.D. Markel, B. Nemke, J.S. Lee, B.K. Graf, W.L. Murphy. Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model, Arthroscopy, 2009; 20: 1427-34.
• J.S. Lee, J.S. Lee, W.L. Murphy. Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces, Acta Biomaterialia, 2010; 6: 21-28.
• W.J. King, L. Jongpaiboonkit, W.L. Murphy. Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreading, Journal of Biomedical Materials Research A, In press.
• W.J. King, N.J. Pytel, K. Ng, W.L. Murphy. Triggered drug release from dynamic microspheres via a protein conformational change. Macromolecular Bioscience, In Press, 2009.

Selected Awards, Honors and Societies

• 2003 NIH National Research Service Award
• 2005 IADR/AADR William J. Gies Award
• 2008 NSF CAREER award
• 2010 Vilas Associates Award
• Editorial Boards: Advanced Functional Materials, Acta Biomaterialia, NanoLIFE, Biomatter
• Member: American Chemical Society Society for Biomaterials Biomedical Engineering Society Materials Research Society

Files and Links of Interest

• Lab Description
• Murphy Lab Homepage

Date last modified: 15-Mar-2012 Content by: wlmurphy@wisc.edu Accessibility Web services Copyright 2011 The Board of Regents of the University of Wisconsin System SEND AN UPDATE REQUEST.