Peter Muir Associate Professor Address/E-mail Program Affiliations Education Fields of Interest Publications Summary >>> Extended Homepage <<<

Contact Information

4270B Veterinary Medicine Building 2015 Linden Drive Madison, WI 53706

Tel: 608/263-9819 Fax: 608/263-7930 E-mail: muirp@svm.vetmed.wisc.edu

Program Affiliations

• Biomedical Engineering
• Animal Health and Biomedical Sciences

• Biomedical Engineering Center
• School of Veterinary Medicine

Education

• BVSc, 1985, University of Bristol, UK
• PhD, 1990, University of Bristol, UK
• MVetClinStud, 1992, The University of Sydney, Australia
• Residency in Small Animal Surgery, Univesity of Wisconsin-Madison, Diplomate, American College of Veterinary Surgeons, 1995

Fields of Interest

• Targeted remodeling of bone
• Functional adaptation to bone fatigue
• Bacteria-associated inflammatory arthritis
• Anterior cruciate ligament rupture

Publications

• Danova NA, Colopy SA, Radtke CL, Kalscheur VL, Markel MD, Vanderby Jr. R, McCabe RP, Escarcega AJ, Muir P. Degradation of bone structural properties by accumulation and coalescence of microcracks. Bone 2003;33:197-205.
• Stepnik MW, Radtke CL, Scollay MC, Oshel PE, Albrecht RM, Santschi EM, Markel MD, Muir P. Scanning electron microscopic examination of third metacarpal/third metatarsal bone failure surfaces in Thoroughbred racehorses with condylar fracture. Veterinary Surgery 2004;33:2-10.
• Dwyer KW, Provenzano PP, Muir P, Valhmu WB, Vanderby Jr. R. Blockade of the sympathetic nervous system degrades ligament in a rat MCL model. Journal of Applied Physiology 96:711-718.
• Colopy SA, Benz-Dean J, Barrett JG, Sample SJ, Lu Y, Danova NA, Kalscheur VL, Vanderby Jr. R, Markel MD, Muir P. Response of the osteocyte syncytium adjacent to and distant from microcracks during adaptation to cyclic fatigue loading. Bone 2004;35:881-891.
• Da Costa Gómez T, Barrett JG, Sample SJ, Radtke CL, Kalscheur VL, Lu Y, Santschi EM, Scollay MC, Markel MD, Muir P. Up-regulation of site-specific remodeling without accumulation of microcracking and loss of osteocytes. Bone 2005;37:16-24.
• Muir P, Danova NA, Argyle DJ, Manley PA, Hao Z. Collagenolytic gene expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture. Veterinary Surgery 2005;34:482-490.
• Barrett JG, Hao Z, Graf BK, Heiner JP, Kaplan LD, Muir P. Inflammatory changes in ruptured canine and human anterior cruciate ligaments. American Journal of Veterinary Research 2005;66:2073-2080.
• Clark WD, Smith EL, Linn KA, Paul-Murphy JR, Muir P, Cook ME. Osteocyte apoptosis and osteoclast-like appearance in chicken radii following osteotomy. Calcified Tissue International 2005;77:327-336.
• Muir P, McCarthy J, Radtke CL, Markel MD, Santschi EM, Scollay MC, Kalscheur VL. Role of endochondral ossification of articular cartilage and adaptation of the subchondral plate in the development of fatigue microcracking of joints. Bone 2006, in press.

Summary

Dr. Muir is the Co-Director of the Comparative Orthopaedic Research Laboratory. His research is focused on functional adaptation of load-bearing connective tissue. Dr. Muir is particularly interested in the biological responses to bone fatigue and the mechanisms that lead to development of fatigue or stress fractures. Dr. Muir is also interested in the mechanisms by which persistent synovitis induces pathological changes in the anterior cruciate ligament and development of progressive ligament rupture.