Masters, Kristyn S.

Postdoctoral research 2001-2003, Chemical Engineering, University of Colorado-Boulder
Ph.D. 2001, Chemical Engineering, Rice University
B.S. 1997, Chemical Engineering, University of Michigan-Ann Arbor

Fields of Interest

Synthesis of bioactive materials that direct cell function
Characterization of cell-material interactions
Tissue Engineering
Drug Delivery

Selected Awards, Honors and Societies

2010 Polygon Outstanding Professor Award
2009 UW-Madison Division of Housing Honored Instructor Award
2009 Emil H. Steiger Distinguished Teaching Award, UW-Madison
2008 Outstanding New Educator Award, ASEE North Midwest Section
2008 ASEE (National) Biomedical Teaching Award
2007 Number One "Hot Talk/Cool Paper" at Materials Research Society Fall 2007 meeting
2006 Scholar, Institute for Scholarship in Engineering Education
2006 NSF CAREER Award
2005 UW Teaching Academy Award
2005 UW Women and Science Teaching Development Award

Selected Publications

Monzack EL, Masters KS. Can valvular interstitial cells become true osteoblasts?: A side-by-side comparison. J Heart Valve Dis, In Press.
Xu F, Flanagan CE, Ruiz A, Crone WC, Masters KS. Polyurethane-Dermatan Sulfate Copolymers as Hemocompatible, Non-Biofouling Materials. Macromol Biosci, In Press [doi: 10.1002/mabi.201000313].
Rodriguez KJ, Piechura LM, Masters KS. Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments. Matrix Biol, In Press [doi:10.1016/j.matbio.2010.09.001].
Gu X, Masters KS. Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation. Am J Physiol: Heart Circ Physiol, In Press [doi:10.1152/ajpheart.01178.2009].
Lee M, Stahl SS, Gellman SH, Masters KS. Nylon-3 Copolymers that Generate Cell-Adhesive Surfaces Identified by Library Screening. J Am Chem Soc, 2009;131:16779-16789. (PMC2818409)
Gu X, Masters KS. Regulation of valvular interstitial cell calcification by adhesive peptide sequences. J Biomed Mater Res A, 2010;93:1620-30. (PMC2860685)
Christ KV, Williamson KB, Masters KS, Turner KT. Measurement of Single-Cell Adhesion Strength using a Microfluidic Assay. Biomed Microdevices, 2010;12:443-455.
Puccinelli TJ, Bertics PJ, Masters KS. Regulation of Keratinocyte Signaling and Function via Changes in Epidermal Growth Factor Presentation. Acta Biomaterialia, 2010;6:3415-3425. (PMC2910130)
Xu F, Hart K, Flanagan CE, Nacker JC, Moftakhar R, Aagaard-Kienitz B, Consigny D, Grinde J, Crone WC, Masters KS. A Hybrid Coil/Polymer Device for Occlusion of Cerebral Aneurysms. J Med Dev, 2009;3: Article 045001.
Chuang TW, Masters KS. Regulation of Polyurethane Hemocompatibility and Endothelialization by Different Molecular Weights of Tethered Hyaluronic Acid. Biomaterials, 2009;30:5341-51.
Gu X, Masters KS. Role of the MAPK/ERK pathway in the calcification of valvular interstitial cells. Am J Physiol: Heart Circ Physiol, 2009;296:H1748-1757.
Stacey DH, Hanson SE, Lahvis G, Gutowski KA, Masters KS. In vitro Adipogenic Differentiation of Preadipocytes Varies with Differentiation Stimulus, Culture Dimensionality, and Scaffold Composition. Tissue Engineering, In Press. doi:10.1089/ten.TEA.2008.0293
Monzack EL, Gu X, Masters KS. Efficacy of statin treatment of valvular interstitial cells varies with the extracellular environment. Arterioscler Thromb Vasc Biol, 2009; 29: 246-253. (featured on cover)
Rodriguez KJ, Masters KS. Regulation of valvular interstitial cell mineralization by components of the extracellular matrix. J Biomed Mater Res A, 2009;90:1043-1053.
Stefonek-Puccinelli TJ, Masters KS. Co-immobilization of gradient-patterned growth factors for directed cell migration. Ann Biomed Eng, 2008; 36: 2121-2133.
Xu F, Nacker JC, Crone WC, Masters KS. The Haemocompatibility of Polyurethane-Hyaluronic Acid Copolymers. Biomaterials, 2008; 29: 150-160.
Stefonek TJ, Masters KS. Immobilized Gradients of Epidermal Growth Factor Promote Accelerated and Directed Keratinocyte Migration. Wound Repair Regen, 2007; 15: 847-855.
Sebra RP, Reddy SK, Masters KS, Bowman CN, Anseth KS. Using Controlled Polymerization Chemistry to Graft Architectures that Influence Cell-Material Interactions Acta Biomaterialia, 2007; 3:151-61.
Sebra RP, Masters KS, Bowman CN, Anseth KS. Rapid antigen detection in a biologically complex fluid using photografted whole antibodies. Anal Chem, 2006; 78: 3144-3151.
Sebra RP, Masters KS, Bowman CN, Anseth KS. Surface Grafted Antibodies: Controlled Architecture Permits Enhanced Antigen Detection. Langmuir 2005; 21: 10907-10911.
Masters KS, Murphy WL. Tissue Engineering. In: Webster JG, editor. Encyclopedia of Medical Devices and Instrumentation, 2nd edition, Volume 6. Wiley-Interscience Publishers, 2006.
Cushing MC, Jaeggli MP, Masters KS, Leinwand LA, Anseth KS. Serum deprivation improves seeding and repopulation of acellular matrices with valvular interstitial cells. J Biomed Mater Res 2005; 75A: 232-241.
Masters KS, Lipke EA, Rice EEH, Liel MS, Myler HA, Zygourakis C, Tulis DA, West JL. Nitric oxide-generating hydrogels inhibit neointima formation. J Biomater Sci Polym Edn, 2005; 16: 659-672.
Masters KS, Shah DN, Anseth KS. Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells. Biomaterials 2005; 26: 2517-2525.
Masters KS, Shah DN, Anseth KS. Designing Scaffolds for Valvular Interstitial Cells: Cell Adhesion and Function on Naturally-Derived Materials. J Biomed Mater Res 2004; 71A: 172-180.
Masters KS, Mann BK. Tissue Engineered Heart. In: Nedovic V, Willaert R, editors. Cell Immobilisation Biotechnology. New York, NY Kluwer Academic Publishers, In Press.
Walker G, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by TGF-beta: Implications for pathological ECM remodeling in heart valve disease. Circ Res 2004; 95: 261-268.
Masters KS, Anseth KS. Cell-Material Interactions. In: Peppas NA, Sefton MV, editors. Molecular and Cellular Foundations of Biomaterials. Advances in Chemical Engineering, Vol. 29. Academic Press, 2004.
Bohl-Masters KS, Leibovich SJ, Belem P, West JL, Poole-Warren LA. The effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. Wound Rep Regen 2002; 10: 286-294.
Bohl-Masters KS, West JL. Pharmacologically active biomaterials. In: Dillow AK, Lowman AM, editors. Biomimetic Materials and Design: Interactive Biointerfacial Strategies, Tissue Engineering and Targeted Drug Delivery. New York, NY: Marcel Dekker, Inc., 2002.
Schmedlen RH, Masters KS, West JL. Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. Biomaterials 2002; 23: 4325-4332.
Tulis DA, Bohl-Masters KS, Lipke EA, Schiesser RL, Evans AJ, Peyton KJ, Durante W, West JL, Schafer AI. YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. Biochem Biophys Res Comm 2002; 291: 1014-1021.
Bohl KS, West J. Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. Biomaterials, 2000; 21 (22): 2273-78.

Summary

By combining engineering and biological principles, my lab investigates fundamental issues in cell-material interactions in order to create 'smarter', bioactive materials that are capable of directing cell function. The projects in my lab entail research in a wide variety of fields, including materials design, biomolecule delivery, and physiological characterization with the end goal of creating unique biomaterial systems with clinical applicability.

Prof. Masters is also faculty co-director of the DELTA program (www.delta.wisc.edu), a learning community which supports current and future science, technology, engineering and math (STEM) faculty in their ongoing improvement of student learning.

Date last modified: 19-Aug-2011
Content by: kmasters@wisc.edu
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