Li, Wan-Ju

Postdoctoral Fellow 2004-2008, NIH, Bethesda, MD
Visiting Research Fellow 2003-2005, NIST, Gaithersburg, MD
Ph.D. 2004, Cell and Tissue Engineering, Thomas Jefferson University, Philadelphia, PA
M.S. 1999, Biomedical Engineering, Drexel University, Philadelphia, PA

Fields of Interest

musculoskeletal tissue engineering
stem cell-based regenerative medicine
nanostructural biomaterial

Publications

* Full-Length Research Papers

1. Caterson EJ, Nesti LJ, Li WJ, Danielson KG, Albert TJ, Vaccaro AR, Tuan RS. Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam. J Biomed Mater Res. 2001; 57(3): 394-403.

2. Tuan RS, Li WJ, Caterson EJ. Mesenchymal stem cell based skeletal tissue engineering. Form J Med. 2001; 5: 662-668.

3. Caterson EJ, Li WJ, Nesti LJ, Albert T, Danielson KG, Tuan RS. Polymer/alginate amalgam for cartilage-tissue engineering. Ann N Y Acad Sci. 2002; 961:134-138.

4. Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J Biomed Mater Res. 2002; 60(4): 613-621.

5. Li WJ, Danielson KG, Alexander PG, Tuan RS. Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(ε-caprolactone) scaffolds. J Biomed Mater Res. 2003; 67A(4): 1105-1114.

6. Tuli R, Li WJ, Tuan RS. Current state of cartilage tissue engineering. Arthritis Res. Ther 2003; 5(5): 235-238.

7. Tuli R, Nandi S, Li WJ, Tuli S, Huang X, Manner P, Laquerriere P, Noth U, Tuan RS. Human mesenchymal progenitor cell-based tissue engineering of a single-unit osteochondral construct. Tissue Eng 2004; 10(7): 1169-1179.

8. Li WJ, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 2005; 26(6): 599-609.

9. Li WJ, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 2005; 26: 5158-5166.

10. Li WJ, Mauck RL, Tuan RS. Electrospun nanofibrous scaffolds: production, characterization, and applications for tissue engineering and drug delivery. J Biomed Nanotechnology 2005; 1: 259-275.

11. Li WJ, Tuan RS. Polymeric scaffolds for cartilage tissue engineering. Macromolecular Symposia 2005; 227: 65-75.

12. Kuo CK, Li WJ, Mauck RL, Tuan RS. Cartilage tissue engineering: its potential and uses. Curr Opin Rheumatol 2006; 18: 64-73.

13. Li WJ, Cooper JA, Mauck RL, Tuan RS. Fabrication and characterization of six electrospun poly(alpha-hydroxy ester) based fibrous scaffolds for tissue engineering. Acta Biomaterialia 2006; 2: 377-385.

14. Li WJ, Jiang, YJ, Tuan RS. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng 2006; 12: 1775-1785.

15. Cooper JA, Li WJ, Bailey LO, Hudson SD, Lin-Gibson S, Anseth KS, Tuan RS, Washburn NR. Encapsulated chondrocyte response to pulsatile flow bioreactor. Acta Biomaterialia 2007; 3: 13-21.

16. Christenson EM, Anseth KS, van de Beucken JJ, Chan CK, Ercan B, Jansen JA, Laurencin CT, Li WJ, Murugan R, Nair LS, Ramakrishna S, Tuan RS, Webster TJ, Mikos AG. Nanobiomaterial applications in orthopaedics. J Orthop Res 2007; 25: 11-22.

17. Nesti LJ, Caterson EJ, Li WJ, Chang R, D. McCannl, Hoek JB, Tuan RS. TGF-b1 calcium signaling in osteoblasts. J Cell Biochem 2007; 101: 348-359.

18. Cho E, Li WJ. Human stem cells, chromatin, and tissue engineering: boosting relevancy in developmental toxicity testing. Birth Defects Res C Embryo Today 2007; 81: 20-40.

19. Li WJ, Mauck RL, Cooper JA, Yuan X, Tuan RS. Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 2007; 40: 1686-1693.

20. Sheth NP, Mauck RL, Li WJ, Tuan RS, Elliott D, Huffman G. Suture fixation of biodegradable nanofibrous poly-caprolactone scaffolds to bovine meniscus: a novel approach to repairing meniscal tears. Arthroscopy: J Arthroscopic Relat Surg 2006; 22: e24.

21. Shanti RM, Li WJ, Nesti LJ, Wang X, Tuan RS. Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery. J Oral Maxillofac Surg 2007; 65:640-1647.

22. Li WJ, Jiang YJ, Tuan RS. Cell-nanofiber-based cartilage tissue engineering using improved cell seeding, growth factor, and bioreactor technologies. Tissue Eng 2008; 14:639-648.

23. Janjanin S, Li WJ, Morgan, MT, Shanti R, Tuan RS. Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor. J Surg Res 2008; 149: 47-56.

24. Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A 2008;14:1527-1537.

25. Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Tuan RS. In vitro adipose tissue engineering using an electrospun nanofibrous scaffold. Ann Plast Surg 2008;61:566-571.

26. Li WJ, Chiang H, Kuo TF, Lee HS, Jiang CC, Tuan RS. Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study. J Tissue Eng Regen Med 2009;3:1-10.

* Book Chapter

1. Li WJ, Shanti RM, Tuan RS. Electrospinning technology for nanofibrous scaffolds in tissue engineering. In: Challa S.S.R. Kumar, editor. Nanotechnologies for the Life Sciences. Germany: Wiley-VCH Verlag GmbH & Co. KgaA, 2006; 135-187.

2. Chen FH, Song L, Mauck RL, Li WJ, Tuan RS. Mesenchymal stem cells in musculoskeletal tissue engineering. In: Robert Lanza, Robert Langer, Joseph P. Vacanti, editors. Principles of Tissue Engineering, Third Edition. Academic Press, 2007; 823-844.

3. Li WJ, Gollapudi K, Patterson DP, Huang GT, Tuan RS. Cell-based therapies for musculoskeletal repair. In: Anthony Atala, Robert Lanza, James A. Thomson, and Robert M. Nerem, editors. Principles of Regenerative Medicine: Elsevier, 2008; 888-911.

4. Mauck RL, Li WJ, Tuan RS. Microenvironment determinants of cell fate: implications for musculoskeletal tissue engineering. In: Ulrich Meyer, Jarg Handschel, and Peter H. Wiesmann, editors. Fundamental of Tissue Engineering and Regenerative Medicine: Springer, 2009; 529-545.

5. Li WJ and Tuan RS. Fabrication and application of nanofibrous scaffolds in tissue engineering. Current Protocols in Cell Biology: John Wiley & Sons, 2009; (in press)

Selected Awards, Honors and Societies

NIH Fellows Award for Research Excellence (FARE) 2004

NASS Young Investigator Research Award 2008

Copyright 2008 The Board of Regents of the University of Wisconsin System
Date last modified: 06-Jan-2009
Content by: li@ortho.wisc.edu
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