Biomedical Engineering
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Sean B. Fain

 
Sean B. Fain
Associate Professor

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  • Program Affiliations
  • Courses
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    • Contact Information

    1133 Wisconsin Institutes for Medical Research
    1111 Highland Ave
    Madison, WI 53706     		Tel: 608/263-0090
    Fax: 608/265-9840
    E-mail: sfain@wisc.edu

    Program Affiliations

    Courses

    Education

    Fields of Interest

    Functional magnetic resonance imaging (MRI), fast MRI, quantitative imaging, functional lung imaging, perfusion imaging and transplant viability.

    Publications

    1. Busse RF, Debbins JP, Kruger DG, Fain SB, Riederer SJ. Interactive Three-Point Localization of Double-Oblique Sections using MR Fluoroscopy. Magn Reson Med 41:846-849; 1999.

    2. Huston J, Fain SB, Riederer SJ, Wilman AH, Bernstein MA, Busse RF. Carotid Arteries: Maximizing Arterial to Venous Contrast in Fluoroscopically-Triggered Contrast-Enhanced MR Angiography with Elliptical Centric View Ordering. Radiology 211:265-273; 1999.

    3. Busse RF, Kruger DG, Debbins JP, Fain SB, Riederer SJ. A Flexible View Ordering Technique for Fast High-Quality 2DFT MR Fluoroscopy. Magn Reson Med 42:69-81; 1999.

    4. Riederer SJ, Fain SB, Kruger DG, Busse RF. 3D Contrast-Enhanced MR Angiography Using Fluoroscopic Triggering and an Elliptical Centric View Order. Int'l J. Cardiac Imaging 15: 117-129; 1999.

    5. Fain SB, Riederer SJ, Bernstein MA, Huston J. Theoretical Limits of Spatial Resolution in Elliptical-Centric Contrast-Enhanced 3D-MRA. Magn Reson Med 42:1106-1116; 1999.

    6. Riederer SJ, Bernstein MA, Breen JF, Busse RF, Ehman RL, Fain SB, Hulshizer TC, Huston J, King BF, Kruger DG, Shah S. Real-Time Fluoroscopic Triggering of 3D Contrast-Enhanced MRA: Design Specifications and Technical Reliability in 330 Patient Studies. Radiology 215:584-593; 2000.

    7. Huston J, Fain SB, Wald JT, Luetmer PH, Rydberg CH, Covarrubias DJ, Riederer SJ, Bernstein MA, Brown RD, Meyer FB, Bower TC, Schleck CD. Carotid Artery: Elliptical Centric Contrast-Enhanced MR Angiography Compared with Conventional Angiography. Radiology 218:138-143; 2001.

    8. Fain SB, King BF, Breen JR, Kruger DG, Riederer SJ. High-Spatial-Resolution Contrast-Enhanced MR Angiography of the Renal Arteries: A Prospective Comparison with Digital Subtraction Angiography. Radiology 218:481-490; 2001.

    9. Fain SB, Riederer SJ. Dependence of Venous Enhancement on the Field of View in 3D Contrast-Enhanced MRA Using the Elliptical Centric View Order. Magn Reson Med 45: 1134-1141; 2001.

    10. Fain SB, Riederer SJ, Huston J, King BF. Embedded MR Fluoroscopy: High Temporal Resolution Real-Time Imaging During High Spatial Resolution 3D MRA Acquisition. Magn Reson Med 46: 690-698; 2001.

    11. Bernstein MA, Fain SB, Riederer SJ. Effect of Windowing and Zero-Filled Reconstruction of MRI Data on Spatial Resolution and Acquisition Strategy. JMRI 14: 270-280; 2001.

    12. Mazaheri Y, Carroll TJ, Du J, Korosec FR, Block WF, Fain SB, Vigen KK, Grist TM, Hany TF, Aagaard BDL, Strother CM, Mistretta CA. Combined Time-Resolved and High Spatial Resolution 3D MRA using an Extended Adaptive Acquisition. JMRI 15(3):291-301; 2002.

    13. Du J, Carroll TJ, Block WF, Fain SB, Korosec FR, Grist TM, Mistretta CA. Time-Resolved, Undersampled Projection Reconstruction Imaging for High-Resolution CE-MRA of the Distal Runoff Vessels. Magn Reson Med 48(3):516-522; 2002.

    14. Du J, Carroll TJ, Block WF, Fain SB, Korosec FR, Grist TM, Mistretta CA. SNR improvement for multiinjection time-resolved high-resolution CE-MRA of the peripheral vasculature. Magn Reson Med 49(5):909-17; 2003.

    15. Du J, Thornton FJ, Fain SB, Korosec FR, Browning FJ, Grist TM, Mistretta CA. Artifact reduction in undersampled projection reconstruction MR imaging of the peripheral vessels using out-of-FOV suppression. Magn Reson Med 51(5):1071-1076; 2004.

    16. Du J, Fain SB, Gu T, Grist TM, Mistretta CA. Noise reduction in MR angiography with nonlinear anisotropic filtering. JMRI 19(5):632-9; 2004.

    17. Fain SB, Browning FJ, Polzin JA, Du J, Zhou Y, Block WF, Grist TM, Mistretta CA. Floating Table Isotropic Projection Acquisition (FLIPR): A time resolved 3D method for extended field-of-view MRI during continuous table motion. Magn Reson Med 52(5): 1093-1102; 2004.

    18. Gu T, Korosec FR, Block WF, Fain SB, Turk Q, Lum D, Zhou Y, Grist TM, Haughton V, Mistretta CA. PC VIPR: a high-speed 3D phase-contrast method for flow quantification and high-resolution angiography. AJNR 26(4):743-9; 2005.

    19. Holmes J, Sorkness R, Meibom SK, Sundaram SK, Perlman SB, Converse AK, Pyzalski RW, Hahn AD, Korosec FR, Grist TM, Fain SB. Noninvasive Mapping of Regional Response to Segmental Challenge Using MRI and FDG-PET. Magn Reson Med 53(6):1243-50; 2005.

    20. Sadowski EA, Fain SB, Alford SK, Korosec FR, Fine J, Meuhrer R, Djamali A, Hofmann RM, Becker BN, Grist TM. Assessment of acute renal transplant rejection with BOLD MRI: initial experience. Radiology 236(3):911-919; 2005.

    21. Fain SB, Altes T, Panth S, et al. Detection of age-dependent changes in healthy adult lungs with diffusion weighted 3He MRI. Acad Radiol 12(11):1385-1393; 2005.

    22. *Fain SB, Panth SR, Evans MD, Wentland AL, Holmes JH, Korosec FR, O'Brien M, Fountaine H, Grist TM. 3He MRI Detects Early Emphysematous Changes in Asymptomatic Smokers. Radiology 239(3):875-883; 2006.

    *Editorial Comment by E. E. de Lange, "Science to practice: what is new about detecting emphysema?," Radiology, vol. 239, pp. 619-20, 2006.

    23. Newman GC, Hospod FE, Fain SB, Cook T. Optimizing dynamic T2* MR imaging for measurement of cerebral blood flow using infusions for cerebral blood volume. Am J Neuroradiol 27(6):1239-40; 2006 (Jun-July).

    24. Newman GC, Hospod FE, Patlak CS, Fain SB, Pulfer KA, Cook TD, O'Sullivan FJ. Experimental estimates of the constants relating signal change to contrast concentration for cerebral blood volume by T2* MRI. J Cereb Blood Flow Metab 26(6):760-70; 2006 (June).

    25. Djamali A, Sadowski EA, Samaniego-Picota M, Fain SB, Muehrer RJ, Alford SK, Grist TM, Becker BN. Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging. Transplantation 82(5):621-8; 2006 (Sept).

    26. Djamali A, Sadowski E, Muehrer R, Reese S, Smavatkul C, Vidyasagar A, Fain S, Lipscomb RC, Hullett DA, Samaniego-Picota M, Grist T, Becker B. BOLD-MRI assessment of Intrarenal Oxygenation and Oxidative Stress in Patients with Chronic Kidney Allograft Dysfunction. Am J Physiol Renal Physiol 292(2):F513-22; 2007 (Feb).

    27. Holmes JH, Korosec FR, Du J,O'Halloran RL, Sorkness RL, Grist TM, Kuhlman JE, Fain SB, Imaging of lung ventilation and dynamics in a single respiratory cycle using hyperpolarized He-3 MRI. J Magn Reson Imaging. 2007 Sep;26(3):630-6.

    28. O'Halloran RL, Holmes JH, Altes TA, Salerno M, Fain SB. The effects of SNR on ADC measurements in diffusion-weighted hyperpolarized He-3 MRI. J Magn Reson 185(1):42-49; 2007.

    29. Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, and Grist TM. Functional Lung Imaging Using Hyperpolarized Gas MRI. J. Magn Reson Imaging 25(5):910-923; 2007 (May).

    30. Du J, Fain SB, Korosec FR, Grist TM, Mistretta CA. Time-resolved contrast-enhanced carotid imaging using undersampled projection reconstruction acquisition. JMRI 25(5):1093-9; 2007 (May).

    31. Erickson MG, Kurpad KN, Holmes JHH, and Fain SB, A TEM Transmission Line Coil with Double Nuclear Capability, Magn Reson Med 2007 Oct;58(4):800-7.

    32. O'Halloran RL, Wen Z, Holmes JH, Fain SB. Iterative Projection Reconstruction of Time-Resolved Images using Highly Constrained Back Projection (HYPR). Magn Reson Med 2008 Jan;59(1):132-9.

    33. Holmes JH, O'Halloran RL, Brodsky EK, Jung Y, Block WF, Fain SB. 3D hyperpolarized He-3 MRI of ventilation using a multi-echo projection acquisition. Magn Reson Med 2008;59(5):1062-1071.

    34. Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE. Evaluation of Structure-Function Relationships in Asthma using Multidetector CT and Hyperpolarized He-3 MRI. Acad Radiol 2008;15(6):753-762.

    35. Smith MR, Zhai X, HarterR, Sisney G, Elezabye M, Fain SB. A novel MR-guided interventional device for 3D circumferential access to breast tissue. Med Phys. 2008 Aug; 35(8):3779-86.

    36. Busacker A, Newell JD Jr, Keefe T, Hoffman EA, Granroth JC, Castro M, Fain S, Wenzel S. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest. 2009 Jan;135(1):48-56.

    37. Aysola RS, Hoffman EA, Gierada D, Wenzel S, Cook-Granroth J, Tarsi J, Zheng J, Schechtman KB, Ramkumar TP, Cochran R, Xueping E, Christie C, Newell J, Fain S, Altes TA, Castro M. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest. 2008 Dec;134(6):1183-91.

    38. Holmes JH, O'Halloran RL, Peterson ET, Brodsky EK, Bley TA, Francois CJ, Velikina JV, Sorkness RL, Busse WW, Fain SB. Three Dimensional Imaging of Ventilation Dynamics in Asthmatics Using Multi-echo Projection Acquisition with Constrained Reconstruction. Magn Reson Med 2009; Accepted.

    39. O'Halloran RL, Holmes JH, Wu Y-C, Alexander A, Fain SB. Heilum-3 MR q-space Imaging with Radial Acquisition and Iterative Highly Constrained Back-Projection. Magn Reson Med 2009; Accepted.

    40. Wentland AL, Sadowski EA, Djamali A, Grist TM, Becker BN, Fain SB. Quantitative MR Measures of Intrarenal Perfusion in the Assessment of Transplanted Kidneys: Initial Experience. Academic Radiology 2009, In Press.

    Selected Awards, Honors and Societies

    GE Healthcare "Thought Leader" Award (2008).

    Hartwell Foundation Individual Biomedical Engineering Research Award (2007).

    Herbert Stauffer Award for best Science paper in Academic Radiology (2006) awarded by the Association of University Radiologists.

    Image of the year ($10K), Concorde Systems User group, PET/MRI of inflammation and ventilation (2005).

    Sandler Program for Asthma Research, Junior Investigator Award ($150K/year, 3 years) (2004).

    National Cancer Institute/UW Radiological Sciences Post-Doctoral Training Grant (2001).

    International Society for Magnetic Resonance in Medicine (ISMRM), Student Travel Stipend (2000).

    Magna Cum Laude Citation for Poster Exhibition titled, "Carotid MRA: A Decade of Development," 85th annual meeting of the RSNA (1999).

    Undergraduate Research Opportunities Grant (UROP), University of Minnesota - Twin Cities (1994).

    Geological Sciences Department Fellowship, University of California - Santa Barbara (1991).

    Honorable Mention, National Science Foundation Graduate Fellowship Award (1989).

    Office of Naval Research Advanced Training in Molecular Marine Biology Fellowship, Hopkins Marine Station (1988).

    Files and Links of Interest




    Copyright 2009 The Board of Regents of the University of Wisconsin System
    Date last modified: 31-Aug-2009
    Content by: sfain@wisc.edu
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