Weibo Cai Assistant Professor Address/E-mail Program Affiliations Education Fields of Interest Publications Awards & Honors Summary >>> Extended Homepage <<<

Contact Information

Room 7137 1111 Highland Avenue Madison, WI 53705-2275

Tel: 608/262-1749 Fax: 608/265-0614 E-mail: wcai@uwhealth.org

Program Affiliations

• Biomedical Engineering
• Medical Physics
• Radiology

• Chemistry-Biology Interface Training Program
• Materials Science Program
• Molecular Imaging and Nanotechnology Laboratory
• School of Medicine and Public Health

Education

• Ph.D. 2004, University of California - San Diego
• B.S. 1995, Nanjing University, China

Fields of Interest

• Molecular Imaging
• Nanotechnology/Nanomedicine
• Positron Emission Tomography
• Cancer Research
• Radiochemistry

Publications

• Cai W,* Zhang X,* Wu Y, Chen X. A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide (18F-FBEM),and the synthesis of RGD peptide-based tracer for PET imaging of avb3 integrin expression. Journal of Nuclear Medicine, 2006, 47, 1172-1180.
• Cai W, Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Letters, 2006, 6, 669-676.
• Cai W, Wu Y, Chen K, Cao Q, Tice DA, Chen X. In vitro and in vivo characterization of 64Cu-labeled AbegrinTM, a humanized monoclonal antibody against integrin avb3. Cancer Research, 2006, 66, 9673-9681.
• Cai W, Rao J, Gambhir SS, Chen X. How molecular imaging is speeding up anti-angiogenic drug development. Molecular Cancer Therapeutics, 2006, 5, 2624-2633.
• Cai W,* Chen K,* Mohamedali KA, Cao Q, Gambhir SS, Rosenblum MG, Chen X. PET of vascular endothelial growth factor receptor expression. Journal of Nuclear Medicine, 2006, 47, 2048-2056.
• Liu Z,* Cai W,* He L, Nakayama N, Chen K, Sun X, Chen X, Dai H. In-vivo biodistribution and highly efficient tumor targeting of carbon nanotubes in mice. Nature Nanotechnology, 2007, 2, 47-52.
• Hsu AR,* Cai W,* Veeravagu A, Mohamedali KA, Chen K, Vogel H, Hou LC, Tse VCK, Rosenblum MG, Chen X. Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel. Journal of Nuclear Medicine, 2007, 48, 445-454.
• Cai W, Hsu AR, Li ZB, Chen X. Are quantum dots ready for in vivo imaging in human subjects? Nanoscale Research Letters, 2007, 2, 265-281.
• Cai W, Chen K, Li ZB, Gambhir SS, Chen X. Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. Journal of Nuclear Medicine, 2007, 48, 1862-1870.
• Cai W, Chen X. Nanoplatforms for targeted molecular imaging in living subjects. Small, 2007, 3, 1840-1854.
• Cai W, Olafsen T, Zhang X, Cao Q, Gambhir SS, Williams LE, Wu AM, Chen X. PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody. Journal of Nuclear Medicine, 2007, 48, 304-310.
• Liu Z, Davis C, Cai W, He L, Chen X, Dai H. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105, 1410-1415.
• Cai W, Niu G, Chen X. Multimodality imaging of the HER-kinase axis in cancer. European Journal of Nuclear Medicine and Molecular Imaging, 2008, 35, 186-208.
• Cai W,* Guzman R,* Hsu AR, Wang H, Chen K, Sun G, Gera A, Choi R, Bliss T, He L, Li ZB, Maag ALD, Hori N, Zhao H, Moseley M, Steinberg GK, Chen X. Positron emission tomography imaging of post-stroke angiogenesis. Stroke, 2009, 40, 270-277.
• Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. Journal of Nuclear Medicine, 2008, 49, 113S-128S.
• Cai W, Niu G, Chen X. Imaging of integrins as biomarkers for tumor angiogenesis. Current Pharmaceutical Design, 2008, 14, 2943-2973.
• Hong H, Gao T, Cai W. Molecular imaging with single-walled carbon nanotubes. Nano Today, 2009, in press.

Selected Awards, Honors and Societies

• Wisconsin Partnership Program MERC New Investigator Award, 2009
• Top 10 Molecular Imaging Research Papers from the Journal of Nuclear Medicine, 2007
• SNM Young Professionals Committee Best Basic Science Award (1st Place), 2007
• Society of Nuclear Medicine Benedict Cassen Post-Doctoral Fellowship, 2006-2008
• Top10 Most-Cited Articles in Nano Letters, 2006
• Stanford University School of Medicine Dean's Fellowship, 2005-2006

Summary

My research interests focus on the development of multimodality molecular imaging agents (positron emission tomography, optical, and magnetic resonance imaging) for early diagnosis and monitoring the efficacy of therapeutic intervention.

Another area of my research will be in nanomedicine where both imaging and therapeutic components will be integrated into a multifunctional entity.

Date last modified: 19-Aug-2011 Content by: wcai@uwhealth.org Accessibility Web services Copyright 2011 The Board of Regents of the University of Wisconsin System SEND AN UPDATE REQUEST.